Mycobacterium avium ss. paratuberculosis Zoonosis – The HundredYearWar – Beyond Crohn’s Disease

The factitive role of Mycobacterium avium ss. paratuberculosis (MAP) in Crohn’s disease has been debated for more than a century. The controversy is due to the fact that Crohn’s disease is so similar to a disease of MAP-infected ruminant animals, Johne’s disease; and, though MAP can be readily detected in the infected ruminants, it is much more difficult to detect in humans. Molecular techniques that can detect MAP in pathologic Crohn’s specimens as well as dedicated specialty labs successful in culturing MAP from Crohn’s patients have provided strong argument for MAP’s role in Crohn’s disease. Perhaps more incriminating for MAP as a zoonotic agent is the increasing number of diseases with which MAP has been related: Blau syndrome, type 1 diabetes, Hashimoto thyroiditis, and multiple sclerosis. In this article, we debate about genetic susceptibility to mycobacterial infection and human exposure to MAP; moreover, it suggests that molecular mimicry between pro-tein epitopes of MAP and human proteins is a likely bridge between infection and these autoimmune disorders.

Leonardo A. Sechi 1* and CoadThomas Dow2,3
1 Department of Biomedical Sciences, University of Sassari, Sassari, Italy
2 McPherson Eye Research Institute, University ofWisconsin, Madison, WI, USA
3 Chippewa Valley Eye Clinic, Eau Claire, WI, USA

Edited by:
Amélia M. Sarmento, Universidade
Fernando Pessoa, Portugal
Reviewed by:
Willem Van Eden, Utrecht University,
Hridayesh Prakash, University of
Hyderabad, India
Leonardo A. Sechi , Department of
Biomedical Sciences, University of
Sassari, Viale San Pietro 43 b, Sassari
97100, Italy


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